1df.loc[~((df.Product_Num.isin(df2['Product_Num']))&(df.Price.isin(df2['Price']))),:]
2Out[246]:
3 Product_Num Date Description Price
40 10 1-1-18 FruitSnacks 2.99
51 10 1-2-18 FruitSnacks 2.99
64 10 1-10-18 FruitSnacks 2.99
75 45 1-1-18 Apples 2.99
86 45 1-3-18 Apples 2.99
97 45 1-5-18 Apples 2.99
1011 45 1-15-18 Apples 2.99