1In [119]:
2
3common = df1.merge(df2,on=['col1','col2'])
4print(common)
5df1[(~df1.col1.isin(common.col1))&(~df1.col2.isin(common.col2))]
6 col1 col2
70 1 10
81 2 11
92 3 12
10Out[119]:
11 col1 col2
123 4 13
134 5 14
14